Whatever happens today, Arsenal will remain top of the Premier League, but a win would extend the lead over Man City to four points – so there’s plenty of extra motivation for Mikel Arteta’s team.
Here are the official line-ups.
Man Utd: De Gea, Martinez, Fernandes, Rashford, Malacia, Eriksen, Varane, Dalot, Antony, Sancho, McTominay
Subs: Dubravka, Heaton, Lindelof, Maguire, Shaw, Casemiro, Fred, Elanga, Ronaldo
Arsenal: Ramsdale, White, Saliba, Gabriel, Zinchenko, Sambi, Xhaka, Saka, Odegaard, Martinelli, Jesus
Subs: Turner, Tomiyasu, Cedric, Holding, Tierney, Smith Rowe, Vieira, Marquinhos, Nketiah